Biological Technologies Office (BTO)

The Advanced Plant Technologies (APT) program seeks to develop plants capable of serving as next-generation, persistent, ground-based sensor technologies to protect deployed troops and the homeland by detecting and reporting on chemical, biological, radiological, nuclear, and explosive (CBRNE) threats. Such biological sensors would be effectively energy-independent, increasing their potential for wide distribution, while reducing risks associated with deployment and maintenance of traditional sensors. These technologies could also potentially support humanitarian operations by, for example, detecting unexploded ordnance in post-conflict settings. More

The Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT) program supports individual troop readiness and total force health protection by developing technologies to rapidly identify and respond to threats posed by natural and engineered diseases and toxins. A subset of ADEPT technologies specifically support use by personnel with minimal medical training, delivering centralized laboratory capabilities even in the low-resource environments typical of many military operations. The program is part of a portfolio of DARPA-funded research aimed at providing options for preempting or mitigating constantly evolving infectious disease threats. More

The Battlefield Medicine program supports military readiness in far-forward deployed settings by overcoming logistical obstacles to manufacturing and delivery of urgently needed pharmaceutical products used to treat emerging threats. More

The Bioelectronics for Tissue Regeneration (BETR) program will develop technology aimed at speeding warfighter recovery, and thus resilience, by directly intervening in wound healing. To do this, researchers will build an adaptive system that uses actuators to biochemically or biophysically stimulate tissue, sensors to track the body’s complex response to that stimulation, and adaptive learning algorithms to integrate sensor data and dictate intervention to the actuators. More

The Biological Control program seeks to support a wide range of potential Department of Defense (DoD) applications by establishing design and control principles that lead to reliable performance in biological systems. Leveraging technologies developed under this program will enable consistent operation of systems that combat biological threats; speed healing after physical trauma; and support military readiness by complementing the body’s natural defenses against emerging diseases. More