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Live Chain

Source: DARPA | Colie Wertz

 

Research Spotlight

Transforming Battlefield Casualty Care for Modern Warfare

The Challenge

The United States military medical system, statistically the best in history, faces a critical challenge: adapting to the realities of potential large-scale combat operations (LSCO) against near-peer adversaries. 

For two decades, U.S. forces in the Global War on Terror relied on rapid evacuation and forward surgical teams to achieve unprecedented casualty survival rates, enabled by: 

  • Air superiority
  • Uncontested logistics
  • Relatively short distances to advanced medical care

These conditions are not guaranteed in future conflicts. 

Modern warfare, marked by advanced weaponry, anti-access/area denial environments, and a high volume of complex injuries, will strain – and potentially overwhelm – the existing casualty care system.

Why the Live Chain Matters

In future battlefield scenarios, the golden hour – the principle that patients should reach surgery within 60 minutes for optimal outcomes – may become unattainable. Factors such as degraded communications, contested airspace, and advanced weaponry will hinder medical evacuation and limit the ability to stage surgical assets close to the front lines.

The recent conflict in Ukraine offers a stark illustration of these challenges: restricted air movement, targeted medical facilities, and unreliable supply lines are common obstacles.

DARPA believes it is imperative to enhance treatment options at and near the point of injury by providing an easy to administer self-help/first aid and enabling long term patient stabilization in a field environment.

DARPA's Focused Approach

Recognizing this looming gap, DARPA is focusing its investment on the Live Chain: The critical steps of tactical combat casualty care that bridge the gap between injury on the battlefield and arrival at surgical care. 

The Live Chain encompasses self-aid, buddy-aid, medic care, en-route care during evacuation, and ultimately, surgical intervention. 

The aim is to ensure warfighters survive the pre-surgical period despite the increased time between injury and definitive medical care.

Source: DARPA | Colie Wertz

 

Research

DARPA's Live Chain research is targeting technological breakthroughs across several key areas:

Hemorrhage Control | Resuscitation and Stabilization | Pain Management and Anesthesia
Autonomous Systems and AI | Traumatic Brain Injury | Real-time Data


 

Artist’s concept of FSHARP product being deployed for disaster response.

Artist’s concept of FSHARP product being deployed for disaster response. Source: DARPA | Colie Wertz


Hemorrhage Control

Uncontrolled bleeding remains a leading cause of preventable battlefield deaths. 

DARPA investments seek to develop:

  • Advanced hemostatic agents and wound dressings that can rapidly and effectively stop bleeding, even in complex wounds
  • Deployable, shelf-stable, universal whole blood analogs (as explored in the FSHARP program) to overcome logistical challenges associated with traditional blood transfusions
  • Easier methods for battlefield blood donation and transfusion, potentially including enzymatic conversion of blood types to create universal donors

Artist’s concept demonstrating management of a complex polytrauma patient

Artist’s concept demonstrating management of a complex polytrauma patient, starting near the point of injury and continuing throughout the evacuation process, via a single intravascular cannula placed by a field medic. Source: DARPA | Alissa Eckert, MSMI; Jacob Fisher


Resuscitation and Stabilization

Maintaining circulatory function and preventing shock are critical in the prolonged pre-surgical period.

Research focuses on:

  • Automated drug and fluid delivery systems that can administer precise doses of resuscitative fluids, vasopressors, and analgesics under austere conditions (as explored in the GOLDEVAC program)
  • Miniaturized and integrated devices that combine multiple life-support functions in a field-portable package
  • Technologies that push damage control surgery capabilities far forward, allowing medics to perform quick, basic stabilization procedures closer to the point of injury

Artist’s concept of field-ready anesthetic being applied on the battlefield.

Artist’s concept of field-ready anesthetic being applied on the battlefield. Source: DARPA | Alissa Eckert, MSMI; Jacob Fisher


Pain Management and Anesthesia

Effective pain relief and sedation are essential for patient comfort, safety, and the ability to perform necessary medical procedures. 

DARPA is investing in:

Artist's concept of a wounded warrior with a traumatic brain injury. Source: DARPA | Alissa Eckert, MSMI; Jacob Fisher


Traumatic Brain Injury Diagnostics and Management

TBIs are expected to be prevalent in large-scale combat operations.

DARPA seeks to develop:

  • Non-invasive devices that can rapidly diagnose TBIs in the field
  • Innovative therapies to mitigate the effects of TBI and promote recovery

A UH-60A Black Hawk helicopter retrofitted with Sikorsky’s MATRIX autonomy technologies flew without anyone onboard for the first time in February 2022

Funded by DARPA’s Aircrew Labor In-Cockpit Automation System (ALIAS) program, a UH-60A Black Hawk helicopter retrofitted with Sikorsky’s MATRIX autonomy technologies flew without anyone onboard for the first time in February 2022, over the U.S. Army installation at Fort Campbell, Ky. Source: Sikorsky Aircraft | Ted Carlson


Autonomous Systems and AI

Leveraging robotics, artificial intelligence, and human-machine teaming to enhance casualty care capabilities is crucial to meet the challenges of future battlefields. 

DARPA is exploring:

Team member reviews data during DARPA Triage Challenge Night Ambush run

Team member reviews data during DARPA Triage Challenge Night Ambush run. Source: DARPA | Paul Flacks


Real-time Data Collection and Analysis

Accurate and timely data is essential for effective casualty care and for improving the system as a whole. 

DARPA is investing in:

  • Passive sensor technologies that can continuously monitor a patient's vital signs and physiological parameters
  • Advanced algorithms that can analyze sensor data in real-time to identify patterns, predict outcomes, and guide treatment decisions

The Path Forward

DARPA's role is to conduct fundamental research and demonstrate the potential of new technologies. A robust transition strategy is critical to bringing new technology into the hands of the warfighter. 

To accelerate this process, DARPA is actively engaging with researchers, commercial businesses, U.S. military entities, and regulatory bodies to build a collaborative ecosystem. This includes building relationships with potential commercial and industrial manufacturing partners.

Source: DARPA | Colie Wertz

 

Resources

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Programs
  • ABC: Seeks to develop safe, battlefield-ready anesthetics in order to reduce injury-associated trauma and improve combat casualty outcomes
  • ALIAS: Envisions a tailorable, drop-in, removable kit that would promote the addition of high levels of automation into existing aircraft, enabling operation with reduced onboard crew
  • DARPA Triage Challenge: Drives innovations in identifying vital signs of injury, locating and assessing casualties, and transmitting critical data
  • FSHARP: Will develop a deployable, shelf-stable, universal whole blood substitute as a hemorrhage countermeasure to sustain injured warfighters in austere, pre-hospital settings
  • GOLDEVAC: Will yield a single intravascular device and gas exchange (i.e. oxygenation) strategy to address a wide range of life-threatening injuries and buy more time to accomplish medical evacuation
  • In the Moment:  Investigates whether the alignment of artificial intelligence (AI) to individual humans affects willingness to delegate in high-stakes domains
  • Medics Autonomously Stopping Hemorrhage (MASH): Aims to develop robotic systems to autonomously find and stop life-threatening bleeding inside the body, giving injured warfighters a much better chance of survival in combat situations
  • RACER: Will demonstrate game-changing autonomous UGV mobility, focused on speed and resiliency, using a combination of simulation and advanced platforms

 

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