Summary
The objective of the PROtein SEquencing (PROSE) program is to demonstrate molecular readers that can accurately read a broad range of amino acids and post translational modifications (i.e., letters) in sequence for unknown protein samples.
The program will seek hardware demonstrations of novel read element designs integrated with microsystem architectures. The program is open to a wide range of translocation and measurement approaches as well as microsystem designs.
However, these approaches must overcome the challenges associated with reading long protein sequences with high accuracy at high throughput. Additionally, the readers must demonstrate scalability across the broad range of chemical complexity in the protein letter space.