Defense Advanced Research Projects AgencyTagged Content List

Analytics for Data at Massive Scales

Extracting information from large data sets

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03/31/2015
In every population that encounters an infectious organism, a few individuals prove to be resilient—unfazed by that pathogen because they are either resistant to it (their immune systems keep the pathogen from multiplying to dangerous levels) or tolerant (they don’t get as sick as they otherwise might despite carrying high pathogen loads). Conventional disease treatments such as antibiotics have almost exclusively sought to emulate natural resistance by keeping patients’ pathogen levels as low as possible.
The ThoR program seeks to discover biological mechanisms of host tolerance to catalyze the development of novel host-based interventions against emerging pathogens and potential biological threat agents.