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Breakthroughs in the science of programmable gene expression inspired DARPA to establish the PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program with the goal of delivering powerful new defenses against public health and national security threats. DARPA has now selected five teams to develop a range of new medical interventions that temporarily and reversibly modulate the expression of protective genes to guard against acute threats from influenza and ionizing radiation, which could be encountered naturally, occupationally, or through a national security event.
Our deployed service members are exposed to adversary activity and numerous naturally occurring or engineered threats including chemicals, viruses, and bacteria. To protect them, BTO is developing technologies that can rapidly detect and characterize these threats. In addition, BTO is developing novel biological approaches to sense and report adversary activities on land and at sea.