Defense Advanced Research Projects AgencyTagged Content List

Prevention and Therapy

Biomedical technologies designed to thwart initial infection or injury, or enable faster healing afterward

Showing 6 results for Therapy + COVID-19 RSS
The Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT) program supports individual troop readiness and total force health protection by developing technologies to rapidly identify and respond to threats posed by natural and engineered diseases and toxins. A subset of ADEPT technologies specifically support use by personnel with minimal medical training, delivering centralized laboratory capabilities even in the low-resource environments typical of many military operations. The program is part of a portfolio of DARPA-funded research aimed at providing options for preempting or mitigating constantly evolving infectious disease threats.
Viral pathogens pose a continuous and shifting biological threat to military readiness and national security overall in the form of infectious disease with pandemic potential. Today’s limited vaccines and other antivirals are often circumvented by quickly mutating viruses that evolve to develop resistance to treatments that are carefully formulated to act only specific strains of a virus.
The Pandemic Prevention Platform (P3) program aims to support military readiness and global stability through pursuit of novel methods to dramatically accelerate discovery, integration, pre-clinical testing, and manufacturing of medical countermeasures against infectious diseases. P3 confronts the reality that Department of Defense (DoD) personnel are not only deployed around the world for routine operations, but are often among the first responders to outbreaks of emerging or re-emerging disease with pandemic potential (e.g., Ebola). P3 aims specifically to develop a scalable, adaptable, rapid response platform capable of producing relevant numbers of doses against any known or previously unknown infectious threat within 60 days of identification of such a threat in order to keep the outbreak from escalating and decrease disruptions to the military and homeland.
Pathogens with pandemic potential, toxic chemicals, and radioactive materials all endanger public health and pose a threat to national security. Despite investment in the development of medical countermeasures (MCMs) to address these threats, many existing MCMs suffer from limited applicability, insufficient efficacy, requirements for repeat dosing, lengthy and complex manufacturing processes, and logistically burdensome storage requirements. In many cases, unique threats require unique responses, setting up a “one threat, one MCM” paradigm.
United States military forces deploy to remote locations around the world, often in areas where emerging infectious diseases are common. The PREventing EMerging Pathogenic Threats (PREEMPT) program seeks to preserve military readiness by protecting against the infectious disease threat; however, rather than treating people, PREEMPT targets viral pathogens within the animal reservoirs and insect vectors where many diseases originate before they spill over into humans.