Defense Advanced Research Projects AgencyTagged Content List

Prevention and Therapy

Biomedical technologies designed to thwart initial infection or injury, or enable faster healing afterward

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The Technologies for Host Resilience (THoR) Program aims to develop new methods to maintain and optimize force health in the face of new and emerging infectious diseases. The goal is to discover the molecular mechanisms for tolerance of infection in animals, and develop therapeutic strategies that modulate the resilience of humans against infection. This capability would support military readiness by enabling warfighters to weather the storm of infectious diseases in low-resource or remote settings where pathogen-specific therapeutics or intensive care unit capabilities may not be locally available.
Uncontrolled blood loss is the leading cause of death for warfighters on the battlefield, according to the U.S. Army Institute of Surgical Research. The vast majority of such fatalities are from wounds that are not accessible by combat medics for traditional treatments, like direct compression. For example, in the case of internal injuries to the abdominal cavity, medics can neither visualize the damage nor access it to provide treatment. As a result, rapid and uncontrolled blood loss often leads to death before transport from the battlefield to a surgical setting can occur.
Program Manager
Dr. Amy Jenkins joined DARPA as a program manager in the Biological Technologies Office (BTO) in June 2019. Her interests include the development of platforms for combatting infectious disease threats as well as novel manufacturing methods to enable rapid response.
Office Director
Dr. Brad Ringeisen was named Office Director of BTO in June 2019. He joined DARPA as the deputy director of BTO in December 2016.
Program Manager
Dr. Tristan McClure-Begley joined DARPA as a Program Manager in October 2017. His scientific pursuits at the agency involve novel chemical biology approaches to treating disease and injury, and developing methods to accelerate and protect learning and executive functions.