Defense Advanced Research Projects AgencyTagged Content List

Prevention and Therapy

Biomedical technologies designed to thwart initial infection or injury, or enable faster healing afterward

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United States military forces deploy to remote locations around the world, often in areas where emerging infectious diseases are common. The PREventing EMerging Pathogenic Threats (PREEMPT) program seeks to preserve military readiness by protecting against the infectious disease threat; however, rather than treating people, PREEMPT targets viral pathogens within the animal reservoirs and insect vectors where many diseases originate before they spill over into humans.
The Rapid Threat Assessment (RTA) program aims to provide critical information to speed production of medical countermeasures to protect U.S. forces against novel chemical and biological weapons. Such weapons have historically been mass-produced within a year of discovery. Development of countermeasures, however, currently takes far longer. Using current methods and technologies, researchers require decades of study to gain a cellular-level understanding of how new threat agents exert their effects.
The Reliable Central-Nervous-System (CNS) Interfaces (RCI) effort seeks to demonstrate CNS interfaces that dramatically extend their performance and lifetime. RCI includes strategies for reliably recording motor-control information from a variety of sources, such as single-unit action potentials, local field potentials, electrocorticography (ECoG) and electroencephalography (EEG). This effort focuses on developing amputee-relevant behavioral-testing methods to accurately evaluate the reliability of CNS-interface systems prior to testing in the intended patient population.
The Reliable Peripheral Interfaces (RPI) effort seeks to demonstrate peripheral-nervous-system (PNS) interfaces that can reliably extract motor-control information for intuitive control of high-performance upper-limb prosthetics. This effort includes a variety of PNS-interface approaches such as nerve cuffs, penetrating electrode arrays, regenerative interfaces, tissue-engineered biological constructs, non-penetrating devices, invasive electromyography (EMG) and sensory-input (stimulation) systems.
The Reorganization and Plasticity to Accelerate Injury Recovery (REPAIR) program aims to uncover the mechanisms underlying neural computation and reorganization to improve modeling of the brain and our ability to interface with it.