Defense Advanced Research Projects AgencyTagged Content List

Prevention and Therapy

Biomedical technologies designed to thwart initial infection or injury, or enable faster healing afterward

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The Reliable Central-Nervous-System (CNS) Interfaces (RCI) effort seeks to demonstrate CNS interfaces that dramatically extend their performance and lifetime. RCI includes strategies for reliably recording motor-control information from a variety of sources, such as single-unit action potentials, local field potentials, electrocorticography (ECoG) and electroencephalography (EEG). This effort focuses on developing amputee-relevant behavioral-testing methods to accurately evaluate the reliability of CNS-interface systems prior to testing in the intended patient population.
The Reliable Peripheral Interfaces (RPI) effort seeks to demonstrate peripheral-nervous-system (PNS) interfaces that can reliably extract motor-control information for intuitive control of high-performance upper-limb prosthetics. This effort includes a variety of PNS-interface approaches such as nerve cuffs, penetrating electrode arrays, regenerative interfaces, tissue-engineered biological constructs, non-penetrating devices, invasive electromyography (EMG) and sensory-input (stimulation) systems.
The Reorganization and Plasticity to Accelerate Injury Recovery (REPAIR) program aims to uncover the mechanisms underlying neural computation and reorganization to improve modeling of the brain and our ability to interface with it.
The Surviving Blood Loss (SBL) program is developing novel strategies to radically extend the time injured warfighters can survive critical blood loss on the battlefield before initiation of fluid and blood resuscitation. Achieving this goal will allow increased time—as much as hours or days—for evacuation, triage, and initiation of supportive therapies.
The Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) program aims to improve force health by using neurotechnology as the basis for effective, informed, and precise treatments for neuropsychiatric illnesses in military Service members. The effects of such illnesses, brought on by war, traumatic injuries, and other experiences, remain challenging to treat. Current treatment approaches—surgery, medications, and psychotherapy—can often help to alleviate the worst effects of illnesses such as major depression and post-traumatic stress, but they are imprecise and not universally effective. Through SUBNETS, DARPA seeks to generate the knowledge and technology required to deliver relief to patients with otherwise intractable neuropsychiatric illness.