Defense Advanced Research Projects AgencyTagged Content List

Synthetic Biology

Leveraging biotechnology to develop new organisms with unprecedented behaviors and capabilities

Showing 34 results for Syn-Bio RSS
The Biological Robustness in Complex Settings (BRICS) program aims to transform engineered microbial biosystems into reliable, cost-effective strategic resources for the Department of Defense (DoD), enabling future applications in the areas of intelligence, readiness, and force protection. Examples include the identification of the geographical provenance of objects; protection of critical systems and infrastructure against corrosion, biofouling, and other damage; sensing of hazardous compounds; and efficient, on-demand bio-production of novel coatings, fuels, and drugs.
The DoD requires timely and comprehensive threat detection to support overall readiness, counter the spread of disease, and promote stabilization missions. State of the art diagnostic and biosurveillance systems are unable to keep pace with disease outbreaks and fail to support decision-making at the time and place of need. The “Detect It with Gene Editing Technologies” (DIGET) program aims to leverage advances in gene editing technologies to develop field-forward diagnostic and biosurveillance technologies that enable detection of any threat, anytime, anywhere.
The goal of the Engineered Living Materials (ELM) program is to develop living materials that combine the structural properties of traditional building materials with attributes of living systems, including the ability to rapidly grow, self-repair, and adapt to the environment. Living materials represent a new opportunity to leverage engineered biology to solve existing problems associated with the construction and maintenance of our built environments, as well as new capabilities to craft smart infrastructure that dynamically responds to the surroundings.
The Insect Allies program is pursuing scalable, readily deployable, and generalizable countermeasures against potential natural and engineered threats to the food supply with the goals of preserving the U.S. crop system. National security can be quickly jeopardized by naturally occurring threats to the crop system, including pathogens, drought, flooding, and frost, but especially by threats introduced by state or non-state actors. Insect Allies seeks to mitigate the impact of these incursions by applying targeted therapies to mature plants with effects that are expressed at relevant timescales—namely, within a single growing season.
Current and emerging Department of Defense (DoD) capabilities rely upon access to a number of critical, high-value molecules that are often prohibitively expensive, unable to be domestically sourced, and/or impossible to manufacture using traditional synthetic approaches. DARPA’s Living Foundries program aims to enable adaptable, scalable, and on-demand production of such molecules by programming the fundamental metabolic processes of biological systems to generate a vast number of complex molecules that are not otherwise accessible.