Defense Advanced Research Projects AgencyTagged Content List

Apply Biological Complexity at Scale

Relating to insights that can be derived from examining living-system dynamics at an enormous range of spatial, physical and temporal scales

Showing 5 results for Bio-complexity + Therapy RSS
05/25/2018
Protection against many common pathogens and environmental stressors is written into our DNA. Our skin responds to sun exposure. Our immune system mounts defenses when we get the flu. Our bodies inherently work to mitigate the potential for harm caused by these health threats. However, these intrinsic responses are not always quick, robust, or appropriate enough to adequately defend us from harm, which is why many people experience sunburn after intense sun exposure or suffer severe symptoms, even death, following exposure to the flu.
June 13, 2018,
Westin Arlington Gateway Hotel
DARPA’s Biological Technologies Office is hosting a Proposers Day meeting to provide information to potential applicants on the structure and objectives of the new PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program. PREPARE will explore ways to better protect against biological, chemical, or radiological threats by temporarily and reversibly tuning gene expression to bolster the body’s defenses against—or directly neutralize—a given threat. It will focus on four key health challenges as proofs of concept: influenza viral infection, opioid overdose, organophosphate poisoning, and exposure to gamma radiation.
Pathogens with pandemic potential, toxic chemicals, and radioactive materials all endanger public health and pose a threat to national security. Despite investment in the development of medical countermeasures (MCMs) to address these threats, many existing MCMs suffer from limited applicability, insufficient efficacy, requirements for repeat dosing, lengthy and complex manufacturing processes, and logistically burdensome storage requirements. In many cases, unique threats require unique responses, setting up a “one threat, one MCM” paradigm.
Deputy Director
Dr. Brad Ringeisen joined DARPA as the Deputy Director of BTO in December 2016.
Program Manager
Dr. Tristan McClure-Begley joined DARPA as a Program Manager in October 2017. His scientific pursuits at the agency involve novel chemical biology approaches to treating disease and injury, and developing methods to accelerate and protect learning and executive functions.