Defense Advanced Research Projects AgencyTagged Content List

Apply Biological Complexity at Scale

Relating to insights that can be derived from examining living-system dynamics at an enormous range of spatial, physical and temporal scales

Showing 4 results for Bio-complexity + COVID-19 RSS
Panacea is a fundamental research program designed to provide novel, multi-target therapeutics that address under-met physiological needs of Department of Defense operators. To do so, the program is applying a systems-pharmacology approach to address the intrinsic complexity of biological processes and unlock more of the potential drug target space in the human proteome. If it succeeds, it will yield new drugs that address some of the challenging physical demands faced by warfighters, including metabolic stress — as with prolonged exertion at high altitude — and activity-related soft tissue injury and resultant pain and inflammation.
Pathogens with pandemic potential, toxic chemicals, and radioactive materials all endanger public health and pose a threat to national security. Despite investment in the development of medical countermeasures (MCMs) to address these threats, many existing MCMs suffer from limited applicability, insufficient efficacy, requirements for repeat dosing, lengthy and complex manufacturing processes, and logistically burdensome storage requirements. In many cases, unique threats require unique responses, setting up a “one threat, one MCM” paradigm.
09/03/2018
Our deployed service members are exposed to adversary activity and numerous naturally occurring or engineered threats including chemicals, viruses, and bacteria. To protect them, BTO is developing technologies that can rapidly detect and characterize these threats. In addition, BTO is developing novel biological approaches to sense and report adversary activities on land and at sea.
08/28/2020
Service members are subject to extreme physical and cognitive demands during training and deployment. BTO is inspiring technologies to better prepare warfighters by ensuring peak performance and restoring function to injured warfighters