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Dr. John Main has spent his career developing new technologies and businesses. He is currently a Program Manager in the Defense Sciences Office at DARPA where he is responsible for initiating new DARPA programs in the physical sciences and fostering the R&D communities that will support those programs. This is Dr. Main’s second tour as a DARPA Program Manager. His first tour at DARPA began in 2002 and resulted in programs in a broad range of technical areas including biologically inspired materials, fast and efficient human-powered swimming, rapid rooftop access, small-scale power generation, GPS-denied underwater navigation, and human exoskeletons for increased warfighter endurance.