Defense Advanced Research Projects AgencyTagged Content List

Restoration of Function

Biological, prosthetic and other technologies designed to provide function equivalent to function lost due to disease or injury

Showing 35 results for Restoration RSS
03/08/2016
The Histology for Interface Stability over Time (HIST) effort identifies leading mechanisms of interface degradation and failure. HIST teams are also developing new invasive and non-invasive histology methods to assess neural-recording-interface status and performance, accurate predictive models of interface performance, and methods to reduce the time required to assess and develop robust interfaces.
03/08/2016
The Reliable Central-Nervous-System (CNS) Interfaces (RCI) effort seeks to demonstrate CNS interfaces that dramatically extend their performance and lifetime. RCI includes strategies for reliably recording motor-control information from a variety of sources, such as single-unit action potentials, local field potentials, electrocorticography (ECoG) and electroencephalography (EEG). This effort focuses on developing amputee-relevant behavioral-testing methods to accurately evaluate the reliability of CNS-interface systems prior to testing in the intended patient population.
03/08/2016
The Reliable Peripheral Interfaces (RPI) effort seeks to demonstrate peripheral-nervous-system (PNS) interfaces that can reliably extract motor-control information for intuitive control of high-performance upper-limb prosthetics. This effort includes a variety of PNS-interface approaches such as nerve cuffs, penetrating electrode arrays, regenerative interfaces, tissue-engineered biological constructs, non-penetrating devices, invasive electromyography (EMG) and sensory-input (stimulation) systems.
04/23/2020
This announcement seeks revolutionary research ideas for topics not being addressed by ongoing BTO programs or other published solicitations.
10/29/2019
Military service members and veterans face serious occupational trauma; one element in particular relates to the significantly increased risk of acute and chronic neuropsychiatric conditions. Neuropsychiatric conditions in the military are particularly impactful because options for treating them are limited. No therapy currently exists that can deliver rapid relief of neuropsychiatric symptoms and is reasonable for use in a broad spectrum of conditions. Neuropsychiatric conditions are complex, and presentation is highly subject to significant inter-individual variability. Focused Pharma aims to develop new drugs that target specific neurotransmitter receptor signaling modes to deliver near immediate relief that is generalizable across indications and individuals.