Defense Advanced Research Projects AgencyTagged Content List

Neuroscience

Relating to the central and peripheral nervous system, including the brain

Showing 64 results for Neuroscience RSS
Previous efforts to understand brain injuries that result from nonkinetic explosive effects have focused only on a single explanation—blast overpressure. Improvised explosive device (IED)-induced injuries in Iraq, however, do not fit this hypothesis. Evidence indicates that traumatic brain injuries unique to blast exposure do not exhibit typical overpressure injuries, such as damage to gas-filled organs like lungs and bowel. DARPA’s Preventing Violent Explosive Neurologic Trauma (PREVENT) program is comprehensively evaluating the physics of the interaction between an IED blast and the brain and has identified which blast components are associated with neurologic injury.
Improved technology for military uniforms, body armor, and equipment saves the lives of thousands of Service members injured on the battlefield. Unfortunately, many of those survivors come home seriously and permanently wounded, suffering unprecedented rates of limb loss and traumatic brain injury. This crisis has motivated great interest in the science of and technology for restoring sensorimotor functions lost to amputation and injury to the central nervous system.
The Histology for Interface Stability over Time (HIST) effort identifies leading mechanisms of interface degradation and failure. HIST teams are also developing new invasive and non-invasive histology methods to assess neural-recording-interface status and performance, accurate predictive models of interface performance, and methods to reduce the time required to assess and develop robust interfaces.
The Reliable Central-Nervous-System (CNS) Interfaces (RCI) effort seeks to demonstrate CNS interfaces that dramatically extend their performance and lifetime. RCI includes strategies for reliably recording motor-control information from a variety of sources, such as single-unit action potentials, local field potentials, electrocorticography (ECoG) and electroencephalography (EEG). This effort focuses on developing amputee-relevant behavioral-testing methods to accurately evaluate the reliability of CNS-interface systems prior to testing in the intended patient population.
The Reliable Peripheral Interfaces (RPI) effort seeks to demonstrate peripheral-nervous-system (PNS) interfaces that can reliably extract motor-control information for intuitive control of high-performance upper-limb prosthetics. This effort includes a variety of PNS-interface approaches such as nerve cuffs, penetrating electrode arrays, regenerative interfaces, tissue-engineered biological constructs, non-penetrating devices, invasive electromyography (EMG) and sensory-input (stimulation) systems.