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Chemical and biological (CB) threats have become increasingly ubiquitous and diverse. They present a risk to our stability operators in pandemic outbreak scenarios, and our warfighters serving in diverse operating environments. State-of-the-art protective equipment continues to severely limit mobility and performance of the user because of a dependence upon protective garments that are thick, heavy, and cumbersome. The Personalized Protective Biosystem (PPB) program aims to reduce protective equipment needs while increasing protection against existing and future CB threats.