Defense Advanced Research Projects AgencyTagged Content List

Injury and Trauma

Relating to diagnosis and treatment of grievous physical and mental injury

Showing 3 results for Injury + Bio-complexity RSS
11/28/2018
Flying at 50,000 feet, diving deep in the ocean, or hiking for miles with gear through extreme climates, military service members face conditions that place unique burdens on their individual physiology. The potential exists to develop pharmacological interventions to help service members complete their toughest missions more safely and efficiently, and then recover more quickly and without adverse effects, but those interventions must work on complex physiological systems in the human body.
December 14, 2018, 10:00 AM ET,
Executive Conference Center
The Biological Technologies Office is holding a Proposers Day to provide information on the structure and objectives of the Panacea program. Panacea aims to integrate systems pharmacology and advanced medicinal chemistry approaches to expand the human drug target space for therapeutic interventions in the areas of acute management of pain and inflammation and the improvement of physiological endurance under oxygen-limited conditions or environments. Panacea will support the development and proof-of-concept demonstration of a new integrated platform for the rapid prediction, synthesis, and validation of pharmacological interventions.
Panacea is a fundamental research program designed to provide novel, multi-target therapeutics that address under-met physiological needs of Department of Defense operators. To do so, the program is applying a systems-pharmacology approach to address the intrinsic complexity of biological processes and unlock more of the potential drug target space in the human proteome. If it succeeds, it will yield new drugs that address some of the challenging physical demands faced by warfighters, including metabolic stress — as with prolonged exertion at high altitude — and activity-related soft tissue injury and resultant pain and inflammation.