Defense Advanced Research Projects AgencyTagged Content List

Injury and Trauma

Relating to diagnosis and treatment of grievous physical and mental injury

Showing 18 results for Injury RSS
The Electrical Prescriptions (ElectRx) program aims to support military operational readiness by reducing the time to treatment, logistical challenges, and potential off-target effects associated with traditional medical interventions for a wide range of physical and mental health conditions commonly faced by our warfighters. ElectRx seeks to deliver non-pharmacological treatments for pain, general inflammation, post-traumatic stress, severe anxiety, and trauma that employ precise, closed-loop, non-invasive modulation of the patient’s peripheral nervous system.
With a focus on wounded warriors and facilitating their return to military service, the Hand Proprioception and Touch Interfaces (HAPTIX) program is pursuing key technologies to enable precision control of and sensory feedback from sensor-equipped upper-limb prosthetic devices. If successful, the resulting system would provide users near-natural control of prosthetic hands and arms via bi-directional peripheral nerve implants. The program has a strong focus on technology handoff and aims to create and transition clinically relevant technology in support of wounded warriors suffering from single or multiple limb loss.
Panacea is a fundamental research program designed to provide novel, multi-target therapeutics that address under-met physiological needs of Department of Defense operators. To do so, the program is applying a systems-pharmacology approach to address the intrinsic complexity of biological processes and unlock more of the potential drug target space in the human proteome. If it succeeds, it will yield new drugs that address some of the challenging physical demands faced by warfighters, including metabolic stress — as with prolonged exertion at high altitude — and activity-related soft tissue injury and resultant pain and inflammation.
Previous efforts to understand brain injuries that result from nonkinetic explosive effects have focused only on a single explanation—blast overpressure. Improvised explosive device (IED)-induced injuries in Iraq, however, do not fit this hypothesis. Evidence indicates that traumatic brain injuries unique to blast exposure do not exhibit typical overpressure injuries, such as damage to gas-filled organs like lungs and bowel. DARPA’s Preventing Violent Explosive Neurologic Trauma (PREVENT) program is comprehensively evaluating the physics of the interaction between an IED blast and the brain and has identified which blast components are associated with neurologic injury.
The Reorganization and Plasticity to Accelerate Injury Recovery (REPAIR) program aims to uncover the mechanisms underlying neural computation and reorganization to improve modeling of the brain and our ability to interface with it.