Defense Advanced Research Projects AgencyTagged Content List

Infectious Disease

Relating to ailments caused by pathogens

Showing 36 results for Disease + Therapy RSS
02/22/2018
The increasing threat of infectious diseases is intensifying the need for breakthrough technologies and capabilities to protect first responders and equip them with therapeutics that can halt the impact of infectious agents. Current approaches for recent public health emergencies due to infectious diseases have not produced effective preventive or therapeutic solutions in a relevant timescale. Examples from recent outbreaks such as H3N2 (flu), Ebola, and Zika viruses highlight the significant lag in deployment and efficacy of life-saving solutions.
05/25/2018
Protection against many common pathogens and environmental stressors is written into our DNA. Our skin responds to sun exposure. Our immune system mounts defenses when we get the flu. Our bodies inherently work to mitigate the potential for harm caused by these health threats. However, these intrinsic responses are not always quick, robust, or appropriate enough to adequately defend us from harm, which is why many people experience sunburn after intense sun exposure or suffer severe symptoms, even death, following exposure to the flu.
02/19/2019
DARPA has selected five teams of researchers to support PREventing EMerging Pathogenic Threats (PREEMPT), a 3.5-year program first announced in January 2018 to reinforce traditional medical preparedness by containing viral infectious diseases in animal reservoirs and insect vectors before they can threaten humans. Through studies in secure laboratories and simulated natural environments, the PREEMPT researchers will model how viruses might evolve within animal populations, and assess the safety and efficacy of potential interventions.
05/03/2019
Could it be that your scent is just a bit too attractive? It is known that mosquitoes are drawn to certain human chemical odors that lead the insects to sources of food. ReVector, a new program from DARPA’s Biological Technologies Office, intends to diminish that attraction — or even actively repel mosquitoes — by engineering the skin microbiome to temporarily alter chemical production. By modulating the interaction of skin-associated microbes with metabolites from the body, ReVector technologies might lower the incidence of mosquito feeding and thus reduce the opportunity for the insects to transmit diseases such as malaria, dengue, and chikungunya that reduce military readiness.
06/27/2019
Breakthroughs in the science of programmable gene expression inspired DARPA to establish the PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program with the goal of delivering powerful new defenses against public health and national security threats. DARPA has now selected five teams to develop a range of new medical interventions that temporarily and reversibly modulate the expression of protective genes to guard against acute threats from influenza and ionizing radiation, which could be encountered naturally, occupationally, or through a national security event.