Defense Advanced Research Projects AgencyTagged Content List

Infectious Disease

Relating to ailments caused by pathogens

Showing 61 results for Disease RSS
The Prometheus program aims to improve military readiness and force health through development of a prognostic that can determine if an individual is contagious before he exhibits symptoms of illness. DARPA’s goal is to develop a molecular test for determining if an individual is likely to spread disease following exposure to an infectious agent and predict within 24 hours of exposure if that individual will become contagious. That ability to predict contagiousness would allow for specific planning and concentration of resources to prevent the spread of an illness from an individual to a population within the confined settings and close quarters typical of military operations.
Military readiness and national security depend on the health and wellbeing of military servicemembers. The Department of Defense’s (DoD) cumulative investment in personnel comprises the second-largest share of the total defense budget. As such, DoD seeks advances in healthcare to ensure warfighters can operate at peak performance, and by focusing on prevention DoD may contain costs while enhancing readiness. In this context, the Prophecy (Pathogen Defeat) program will explore the evolution of viruses in the hopes of predicting viral mutations and ultimately developing drugs and vaccines in advance of need.
The Rapid Threat Assessment (RTA) program aims to provide critical information to speed production of medical countermeasures to protect U.S. forces against novel chemical and biological weapons. Such weapons have historically been mass-produced within a year of discovery. Development of countermeasures, however, currently takes far longer. Using current methods and technologies, researchers require decades of study to gain a cellular-level understanding of how new threat agents exert their effects.
Mosquitoes transmit pathogens that cause dengue, malaria, and other diseases that present significant risks to the readiness and resilience of military personnel, and public health more generally. The ReVector program aims to maintain the health of military personnel operating in disease-endemic regions by reducing attraction and feeding by mosquitoes.
The Technologies for Host Resilience (THoR) Program aims to develop new methods to maintain and optimize force health in the face of new and emerging infectious diseases. The goal is to discover the molecular mechanisms for tolerance of infection in animals, and develop therapeutic strategies that modulate the resilience of humans against infection. This capability would support military readiness by enabling warfighters to weather the storm of infectious diseases in low-resource or remote settings where pathogen-specific therapeutics or intensive care unit capabilities may not be locally available.