Defense Advanced Research Projects AgencyTagged Content List

Threat Countermeasures

Actions that mitigate adversaries' capabilities

Showing 22 results for Countermeasures + Therapy RSS
June 13, 2018,
Westin Arlington Gateway Hotel
DARPA’s Biological Technologies Office is hosting a Proposers Day meeting to provide information to potential applicants on the structure and objectives of the new PReemptive Expression of Protective Alleles and Response Elements (PREPARE) program. PREPARE will explore ways to better protect against biological, chemical, or radiological threats by temporarily and reversibly tuning gene expression to bolster the body’s defenses against—or directly neutralize—a given threat. It will focus on four key health challenges as proofs of concept: influenza viral infection, opioid overdose, organophosphate poisoning, and exposure to gamma radiation.
Warfighters are travelers, and the bodily inconveniences suffered by travelers, such as jet lag and traveler's diarrhea, can seriously degrade operational readiness and even determine mission success or failure. To maximize warfighter performance, the ADvanced Acclimation and Protection Tool for Environmental Readiness (ADAPTER) program will develop systems that provide warfighters greater control over their own physiology.
Microbial infections are a problem of particular concern to the Department of Defense (DoD). The DoD has long recognized the warfighter’s outsized risk of exposure to infectious disease, including the rise of antimicrobial resistant (AMR) and multidrug resistant (MDR) pathogens that have challenged military wound care in Iraq and Afghanistan. Furthermore, the responsibility of the DoD to protect the homeland encompasses biological threat agents, including bacterial threats, for which effective countermeasures are critical.
The Pandemic Prevention Platform (P3) program aims to support military readiness and global stability through pursuit of novel methods to dramatically accelerate discovery, integration, pre-clinical testing, and manufacturing of medical countermeasures against infectious diseases. P3 confronts the reality that Department of Defense (DoD) personnel are not only deployed around the world for routine operations, but are often among the first responders to outbreaks of emerging or re-emerging disease with pandemic potential (e.g., Ebola). P3 aims specifically to develop a scalable, adaptable, rapid response platform capable of producing relevant numbers of doses against any known or previously unknown infectious threat within 60 days of identification of such a threat in order to keep the outbreak from escalating and decrease disruptions to the military and homeland.
The Pathogen Predators program focuses on force readiness and homeland protection through development of novel countermeasures against biological threats involving bacterial agents. Currently, the most common defense against such a threat is traditional antibiotics, but while such antibiotics have been remarkably effective in the past, their widespread use has heightened the risk of our troops contracting antibiotic-resistant bacterial infections that are difficult or impossible to treat. A new type of countermeasure is needed to overcome the threat posed by antibiotic-resistant bacteria.