Defense Advanced Research Projects AgencyTagged Content List


The identification and transformation of substances

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Health threats often evolve more quickly than health solutions. Despite ongoing research in the government and the biopharmaceutical industry to identify new therapies, the Department of Defense (DoD) currently lacks tools to address the full spectrum of chemical, biological, and disease threats that could impact the readiness of U.S. forces.
Microbial infections are a problem of particular concern to the Department of Defense (DoD). The DoD has long recognized the warfighter’s outsized risk of exposure to infectious disease, including the rise of antimicrobial resistant (AMR) and multidrug resistant (MDR) pathogens that have challenged military wound care in Iraq and Afghanistan. Furthermore, the responsibility of the DoD to protect the homeland encompasses biological threat agents, including bacterial threats, for which effective countermeasures are critical.
Coatings, thin films and advanced surfaces are important aspects of systems, devices and technologies critical to the mission of the Department of Defense. Despite decades of work, methods that enable atomic through millimeter-scale control over structure and properties of materials deposited on surfaces are still underdeveloped. For example, structural organization of high-value thin films is typically controlled by high-temperature deposition or annealing, but the temperatures employed during thin-film synthesis and deposition exceed the limits of many DoD-relevant substrates, restricting application opportunities.
Synthetic chemistry is important across countless technological areas, from medicines to energetics to advanced coatings to functional materials. While our synthetic capabilities have developed rapidly over the last century, current approaches are still slow and inefficient, with poor reproducibility and scalability and limited use of prior knowledge. Such an approach not only limits production of known materials, but also impedes discovery of better synthetic routes and completely new molecules.
The Molecular Informatics program brings together a collaborative interdisciplinary community to explore completely new approaches to store and process information with molecules. Chemistry offers an untapped, rich palette of molecular diversity that may yield a vast design space to enable dense data representations and highly versatile computing concepts outside of traditional digital, logic-based approaches.