Defense Advanced Research Projects AgencyTagged Content List


The identification and transformation of substances

Showing 48 results for Chemistry RSS
Synthetic chemistry is important across countless technological areas, from medicines to energetics to advanced coatings to functional materials. While our synthetic capabilities have developed rapidly over the last century, current approaches are still slow and inefficient, with poor reproducibility and scalability and limited use of prior knowledge. Such an approach not only limits production of known materials, but also impedes discovery of better synthetic routes and completely new molecules.
The Molecular Informatics program brings together a collaborative interdisciplinary community to explore completely new approaches to store and process information with molecules. Chemistry offers an untapped, rich palette of molecular diversity that may yield a vast design space to enable dense data representations and highly versatile computing concepts outside of traditional digital, logic-based approaches.
The U.S. Department of Defense (DoD) develops and uses molecules and materials across a diverse range of areas including therapeutics, electronics, coatings, and fuels. Application areas with particularly unique relevance to national security, such as energetics, tend not to keep pace with the need for innovation and new performance characteristics.
Automation and artificial intelligence are revolutionizing discovery and production of functional molecules by enabling fast, reproducible experimentation and efficient property optimization. These capabilities have already made a significant impact on prevalent molecular classes, such as pharmaceuticals, but niche areas characterized by unique chemical space, limited literature precedence, and requirements for specialized experimental hardware have experienced relatively slow improvement. One such area, critical to national security, is energetics.
The SIGMA+ program aims to expand SIGMA’s advance capability to detect illicit radioactive and nuclear materials by developing new sensors and networks that would alert authorities to chemical, biological, and explosives threats as well.