Targeted Neuroplasticity Training (TNT) seeks to advance the pace and effectiveness of a specific kind of learning—cognitive skills training—through the precise activation of peripheral nerves that can in turn promote and strengthen neuronal connections in the brain. TNT will pursue development of a platform technology to enhance learning of a wide range of cognitive skills, with a goal of reducing the cost and duration of the Defense Department’s extensive training regimen, while improving outcomes. If successful, TNT could accelerate learning and reduce the time needed to train foreign language specialists, intelligence analysts, cryptographers, and others.
The TNT program seeks to use peripheral nerve stimulation to speed up learning processes in the brain by boosting release of brain chemicals, such as acetylcholine, dopamine, serotonin, and norepinephrine. These so-called neuromodulators play a role in regulating synaptic plasticity, the process by which connections between neurons change to improve brain function during learning. By combining peripheral neurostimulation with conventional training practices, the TNT program seeks to leverage endogenous neural circuitry to enhance learning by facilitating tuning of neural networks responsible for cognitive functions.
DARPA is taking a layered approach to exploring this new terrain. Fundamental research will focus on gaining a clearer and more complete understanding of how nerve stimulation influences synaptic plasticity, how cognitive skill learning processes are regulated in the brain, and how to boost these processes to safely accelerate skill acquisition while avoiding potential side effects. The engineering side of the program will concentrate on developing non-invasive methods to deliver peripheral nerve stimulation that enhances plasticity in brain regions responsible for cognitive functions. The goal is to optimize training and stimulation protocols that expedite the rate of learning and maximize long-term retention of cognitive skills.
TNT is part of a broader portfolio of programs within DARPA that support the White House BRAIN initiative.
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