Program Manager: Lt
Col Daniel J. Wattendorf, M.D.
The goal of the Feedback Regulated Automatic Molecular Release program is to develop biodegradable self-regulating drug delivery systems that enable feedback-regulated release in response to a biomarker(s) correlated with drug efficacy and/or toxicity. These systems will enable soldier self-care through the development of drug delivery methods that assure, in the combat environment, the delivery of a therapeutic dose while eliminating the possibility of drug overdose. Delivery systems for one or more of the therapeutics classes that are currently used in tactical field care or battlefield medicine are of particular interest. The early objectives of this project are to demonstrate that the release rate of the drug from the new system is sufficient to achieve therapeutic levels, but can be reduced by an amount sufficient to avoid toxicity (e.g., > 10:1) in the presence of a biomarker correlated to a toxic effect.
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