Program Manager: Jon Mogford, Ph.D.
The Restorative Injury Repair program will achieve its goals by developing a comprehensive understanding of the wound environment, including cellular elements, matrix, inflammatory mediators, growth factors, nutrients, substrate utilization, biofilms, and ultimately processes of morphogenesis leading to anatomic and functional restoration. Phase I accomplishments include demonstrating formation of a blastema at a non-regenerating wound site in a mammal; Phase II efforts are focused on full restoration of a functional multi-tissue structure in a mammal.
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