THoR Aims to Help Future Patients “Weather the Storm” of Infection
In every population that encounters an infectious organism, a few individuals prove to be resilient—unfazed by that pathogen because they are either resistant to it (their immune systems keep the pathogen from multiplying to dangerous levels) or tolerant (they don’t get as sick as they otherwise might despite carrying high pathogen loads). Conventional disease treatments such as antibiotics have almost exclusively sought to emulate natural resistance by keeping patients’ pathogen levels as low as possible. This approach has been incredibly successful but has an increasingly serious downside: Any pathogens that survive a particular treatment can defy it from then on, giving rise to new antibiotic-resistant strains. The rising prevalence of multi-drug-resistant pathogens, as well as emerging biological threats, makes developing new medical countermeasures a national security priority. Article