• Biological Technology Office (BTO)
  • Biochronicity

    Military readiness and national security depend on the health and wellbeing of military servicemembers.  DoD’s cumulative investment in personnel comprises the second-largest share of the total defense budget.  As such, DoD seeks advances in healthcare to ensure warfighters can operate at peak performance.  In this context, the Biochronicity program will explore the role of time in biological functions in pursuit of breakthroughs in managing the effects of time on human physiology.

    Military readiness and national security depend on the health and wellbeing of military servicemembers.  DoD’s cumulative investment in personnel comprises the second-largest share of the total defense budget.  As such, DoD seeks advances in healthcare to ensure warfighters can operate at peak performance.  In this context, the Biochronicity program will explore the role of time in biological functions in pursuit of breakthroughs in managing the effects of time on human physiology.

    Time is a fundamental variable in all science, including biology.  Biological clocks regulate almost every function in the human body, yet scientists lack a clear understanding of the coordination of timing on multiple scales to influence processes such as cell-cycle progression, growth, metabolism, aging and cell death. 

    The Biochronicity program is an interdisciplinary research effort that seeks to identify common spatio-temporal instructions, or “clock signatures,” in biological organisms by using empirically derived data, as well as bioinformatics and data-mining techniques.  Early phases of the program will aim to identify and validate networks of temporal regulators to enable development of predictive algorithms for time-dependent processes in biological organisms.  

    Fundamental advancements in the understanding of timing in biology could potentially contribute to many defense imperatives, including enhancing human combat performance, improving trauma care on the battlefield by expanding the window of opportunity for medical treatment and surgical intervention, and understanding the mechanisms behind disease and managing their effects.

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